They soon reunite with Teddy (Zac Efron) to help battle the sorority sisters of Kappa Kappa Nu, led by Shelby (Chloë Grace Moretz), who moved in to their neighboring house.
Kappa Kappa Nu is a new sorority that branched off from Phi Lambda Phi, led by Madison (Selena Gomez).
- Seth Rogen as Mac Radner
- Zac Efron as Teddy Sanders, the former leader of Delta Psi Beta.
- Rose Byrne as Kelly Radner
- Chloë Grace Moretz as Shelby, the leader of Kappa Kappa Nu.
- Dave Franco as Pete Regazolli, the former member of Delta Psi Beta.
- Ike Barinholtz as Jimmy Blevins
- Carla Gallo as Paula Faldt
- Kiersey Clemons as Beth, a member of Kappa Kappa Nu.
- Beanie Feldstein as Nora, a member of Kappa Kappa Nu.
- Selena Gomez as Madison, the president of Phi Lambda Phi.
- Lisa Kudrow as Dean Carol Gladstone
- Hannibal Buress as Officer Watkins
- Jerrod Carmichael as Garf
- Abbi Jacobson
- Cameron Dallas
- Billy Eichner
- Clara Mamet
- Nora Lum
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